PURADISC® BIO SD
PURADISC® BIO SD is the first depth filter using the advantages of the alluvial (specifically cake or precoat) filtration technology in a disposable format. The filtration system removes particles (e.g. cells, bacteria,yeast), impurities like HCP, DNA and other turbid matter. With BIO SD, this technology is now also available for single-use cell separation. In addition, the system is fully scalable and disposable, it fulfills all validation requirements. The transfer from the method development stage into large-scale processes can be easily achieved due to linear scalability.
Typical applications are for example, CHO cell removal, bacterial removal and may more. In addition, this system is completely disposable. In other words, all material that comes in contact with the product is meant for single-use and can be disposed of after the filtration is compleated. As a result, this reduces cross-contamination risks, cleaning validation efforts and downtime during filter changes. Therefore, this method is the ideal choice for contract manufacturers (CMO) and other operations with a high frequency of product range.
Advantages
- Flexibility
- Filter area / space for filter cake
- Connectors (certainly, fits all common single-use systems)
- Retention rate
- Very small dead volumes
- Widely scalable (lab to production also non single-use systems)
- Well known and accepted technology (therefore no validation risks)
- Removes cells and impurities (e.g. HPC) in one step / e.g. up to 30–40% HPC from the fermentation broth
- No need for pH changes nor flocculants
- Variable operation possibilities (alluvial filtration, likewise sheet filtration)
- Reduce overall costs and downtime
- Eliminates cleaning validation and therefore reduction of cross contamination risk
- Available also as a skid version (incl. pump and control unit)
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First in the live science industry to introduce body feed filtration for Midstream applications
in a single-use format.
“It’s like building your depth filter.”
(Comment from a famous US biotech company)
Application examples
- CHO cell removal
- Bacteria (e.g. E.coli) removal
- Cell debris removal
- Insect cells removal
- Plasmid DNA purification
- Yeast removal
- And others
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Filter modules and capsules product range
PURACAP® 2″ Capsule
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Batch range [liter] | Up to 2 L |
| Cake volume [liter] | 0.06 | |
| Filter area m² | 0.002 | |
| Application | Proof of technology, evaluation of DE grade |
PURACAP® 5″ Capsule
 |
Batch range [liter] | Up to 10 L |
| Cake volume [liter] | 0.38 | |
| Filter area m² | 0.0127 | |
| Application | Evaluation of 2″ results, small pilot scale |
PURACAP® 10″ Capsule
 |
Batch range [liter] | Up to 20 L |
| Cake volume [liter] | 1.5 | |
| Filter area m² | 0.05 | |
| Application | For customers using fermenter farms up to 30 L |
PURADISC® 12″ Short module – 12M
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Batch range [liter] | Up to 100 L |
| Cake volume [liter] | 3.5 | |
| Filter area m² | 0.33 (up to 0.675) | |
| Application | Pilot scale |
PURADISC® 12″ Single module – 12S
 |
Batch range [liter] | Up to 200 L |
| Cake volume [liter] | 9.9 | |
| Filter area m² | 0.55 (up to 1.8) | |
| Application | Bio process scale |
PURADISC® 12″ Double module – 12D
 |
Batch range [liter] | Up to 500 L |
| Cake volume [liter] | 19.8 | |
| Filter area m² | 1.1 (up to 3.6) | |
| Application | Bio process scale |
PURADISC® 16″ Double module – 16D
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Batch range [liter] | Up to 1000 L |
| Cake volume [liter] | 40.7 | |
| Filter area m² | 2.26 (up to 7.2) | |
| Application | Bio process scale |
Support systems
For the use of PURADISC® BIO SD single-use modules, special stainless steel housings are necessary.
DISCSTAR® BIO SD 12″ short support system
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Max. operating pressure | 0 – 3 bar |
| Capacity | 13.6 L (empty housing) | |
| Weight | 35 kg | |
| Material | Stainless steel AISI 304 |
DISCSTAR® BIO SD 12″ double support system
 |
Max. operating pressure | 0 – 3 bar |
| Capacity | 51 L (empty housing) | |
| No. of modules | 1 × 12″ (double module) | |
| Material | Stainless steel AISI 304 | |
| Also available as single version for single modules. | ||
DISCSTAR® BIO SD 16″
 |
Max. operating pressure | 0 – 3 bar |
| Capacity | 90 L (empty housing) | |
| No. of modules | 2 × 16″ | |
| Material | Stainless steel AISI 304 |
