Choose from 6 different ACTIVASORB® filter sheets and carry out filtration tests on a laboratory scale. Achieve the results you need for seamless filtration process development with ease and simplicity. The ACTIVASORB Test-Kit contains:
Last week marked again a milestone in FILTROX history as we unveiled our new production line at our facility in Tlalnepantla, Mexico! It was an honor to host guests from the U.S., Mexico, Peru, Colombia, Guatemala, the Dominican Republic, and Brazil, including esteemed officials, suppliers, partners, and distributors. His Excellency Piero Piffaretti, the Swiss Ambassador to Mexico, joined José Maria Padilla of the State of Mexico and Carmen Ugalde of Tlalnepantla City for the ribbon-cutting ceremony.
A huge thank you to the organizing committee for their stellar preparation, and to the entire FILTROX Team in Mexico for their outstanding hospitality! This achievement is a testament to the power of teamwork.
Finding the right depth filter is not easy and often time-consuming. The FILTROX Scale-up Test Kit supports you in finding the best depth filter solution for your application in a simple and efficient way, whether depth filtration or alluvial filtration.
With the included material, you can start with 20 mL experiments and scale-up the results to your desired batch size.
This application note is about the clarification of a 3 herb extract for cosmetic products using depth filtration. In collaboration with WELEDA in Arlesheim, Switzerland
Simon Sauter completes management buy-out
We are pleased to inform you that the management buy-out process of Schmid Automation AG, which has started five years ago, has now been completed. Simon Sauter takes over the entire business, including its subsidiaries Schmid Automation GmbH, Augsburg and Schmid Schaltanlagen AG, St. Gallen, retroactively per 1st of November 2022. Simon Sauter has been Managing Director of Schmid Automation since 2017 and already held a minority stake in the company. Until now, the remaining shares belonged to FILTROX Holding AG. In the future, FILTROX wants to focus entirely on its core business, which is depth filtration of valuable liquids.
“Simon Sauter is the ideal owner for Schmid Automation AG. As an experienced engineer and
long-standing managing director, he is perfectly prepared to lead the company successfully
into the future”, Dr. Cristian Rusch, CEO of FILTROX, is quoted. Simon Sauter adds: “It gives
me great pleasure to further develop the topics of digitalization for the benefit of our
customers with our highly motivated team”. …
This Application Note is of how to make a correct upscale for depth filtration in the lab. The described filtration trials of the yeast cell suspension have shown that a linear scale-up of a depth filtration step is feasible.
This Application Note is about turbidity reduction of herbal extracts and of how to purify plant extracts using depth filtration. The aim is to retain the flavors and fragrance of the valuable herbs while filtering out all solid particles.
In a second step, the generated results of the lab scale filtration tests were used for a scale-up calculation to a batch size of 100 L for each herbal extract.
In this Application Note, the optimization of the filtration process of a mAb-contained CHO cell culture is shown in detail. So far, the suspension is filtered in three steps, before a sterile filtration using a 0.2 μm membrane is applicable. To ensure the sterile filtration step, a flocculant has to be added prior to each filtration. In order to reduce the number of process steps in the cell harvest process, filtration tests with FILTROX depth filter sheets are performed in the laboratory scale.
The aim is to determine the most suitable filter aid and its ideal quantity for the cell culture. And, in addition, to achieve turbidity values below 30 NTU to ensure subsequent sterile filtration.
About CBD Oil clarification and purification
Raw hemp extracts contain high concentrations of cannabinoids but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Discover our optimized 2-step filtration and purification solution to remove the unwanted contaminants and color.
An example of how such a filtration can be carried out. (PDF)
About clarification and purification of natural extracts
Raw hemp extracts contain high concentrations of cannabinoids but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Discover our optimized 2-step filtration and purification solution to remove the unwanted contaminants and color.
An example of how such a filtration can be carried out. (PDF)
Optimized solutions for Plasmid- DNA clarification and purificationPURADISC® BIO SD is the state-of-the-art technology for alluvial filtration for Plasmid-DNA clarification. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX® depth filters are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m2 filter area can be drastically increased. |
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Save one process step |
Find out more on our PURADISC® BIO SD webpage or contact our filtration experts:
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These instruction videos show you, how to install FILTRODISC™ lenticular modules with DOE or DOR adapter into a DISCSTAR™ housing.
Read the new Paper of the Royal Society of Chemistry about a novel instrumental analytical endotoxin quantification assay.
Single-use and traditional approach of clarificationThe ongoing optimization of mammalian cell lines and fermentation processes leads to higher cell densities/titers and higher monoclonal antibody (mAb) yields. Due to this optimization also the biomass increases, including cell debris and other impurities, which challenges the clarification/harvest step. |
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The typical clarification process for mammalian cells and mAb involves a primary and a secondary clarification step. Due to potentially high shear forces and the necessity of this step to remove submicron particles, depth filtration is a mandatory step before transferring the liquid into the downstream. |
The process combines low running costs with operating robustness.
Find out more on our webpage or contact our filtration experts:
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LINKS AND DOWNLOADS:
LEAFLET MAMMALIAN CELLS AND MAb CLARIFICATION
MORE ABOUT THE CLARIFICATION SOLUTIONS FOR MAMMALIAN CELLS AND MAb’s
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Clarification for vaccines – the economic and efficient removal of cell debris and negatively charged molecules with FILTRODISC™ BIO SD and FILTRODISC™ R2U depth filter modules. |
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The purification of vaccines is a critical step during their complex production process. Cells and cell debris, as well as unwanted contaminants such as host cell proteins (HCPs) and nucleic acids need to be removed, while ensuring an optimal product yield. FILTROX offers a variety of filtration solutions to meet the specific needs for vaccine clarification. A well-established and efficient technology is alluvial (or body feed) filtration with filter aids such as diatomaceous earth. Lenticular filter modules (FILTRODISC™) can be easily applied to combine the exceptional filtration capacity of filter aids with the advantages of using an enclosed filter housing (DISCSTAR™). To further optimize pharmaceutical processes, the single use filter modules FILTRODISC™ BIO SD for alluvial filtration and FILTRODISC™ R2U (Ready2Use) for standard depth filtration of less turbid fluids are the best solution for eliminating cross-contamination risks and reducing cleaning validation efforts. This technology is easy to implement and linear scalable from lab to production. |
Linear scale up
from lab to production.
Reduction of costs and production steps
by saving the centrifuge step.
Single-use solution
eliminates cross-contamination risks and reduces cleaning validation efforts.
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SPECIFIC IMPURITIES TO REMOVE? To address the removal of specific impurities, filter sheets containing adsorbants with functional properties such as cationic resins (PURAFIX® CH ZP) and activated carbon (CARBOFIL™) are used. |
Find out more on our webpage or contact our filtration experts:
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LINKS AND DOWNLOADS:
ABOUT ALLUVIAL FILTRATION (PDF download)
BROCHURE CARBOFIL™ (PDF download)
From laboratory to production scale. How to find the optimal solution for your filtration process. From laboratory trials to estimate the perfect filter sheet to calculation for your individual production scale. Read the application note: https://bit.ly/2XS4leh
An Economical Solution for Midstream Clarification
Introduction
Continuous process optimization is a key factor in the biotech industry. With higher particle loads (>108 cells/ml), standard technologies for cell removal (midstream processing) – e.g. centrifugation, separation, membrane- and depth filtration – find their limits.
To increase efficiency and making the midstream process more economical alluvial filtration is the state-of-the-art solution. Alluvial filtration is a type of depth filtration and a well-established, econo-mical method in pharmaceutical industries (e.g. plasma fractionation). Instead of using an immobilized depth filter medium, filter aid (e.g. diatomaceous earth, perlite) is used to constantly build a filter cake during filtration. The filter cake with its resistance acts then as the actual filter medium. Alluvial filtration, therefore, leads to a higher filter capacity – especially with compressible particles, e.g. microbial or mammalian cells. This technology leads to a maximum product yield and highest economic efficiency and is linear scalable from lab to production scale.
Producing pure and safe CBD products is the goal of every quality-conscious manufacturer of cannabis products. Raw hemp extracts contain high concentrations of cannabinoids, but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Why certain contaminants should be removed:
Chlorophyll:
• bitter taste and highly unstable
• will cause degradation of cannabinoids
Waxes:
• very sticky components
• removal leads to smoother texture and consistency
Filtration and purification steps of CBD products and oils
In order to ensure product quality and safety, filtration is essential. To remove the waxes, fats and oil from the winterization a multi-step filtration is recommended. Depending on the batch size different approaches are possible. Find out more about the filtration steps. more…
Would you like to get to know us personally and find out more about our depth filtration solutions? Visit us at MJBizCon in Las Vegas, Dec 11-13, 2019 / Stand C9238. MJBizCon, is the largest gathering of cannabis business professionals in the world. With 35,000 attendees and programming to benefit every sector, there is no place like it to equip your business for growth. We look forward to meeting you there. more about MJBizCon
How optimization of the filtration step saves time and reduces operating costs. Download the application note.
