Optimized solutions for Plasmid- DNA clarification and purification
PURADISC® BIO SD is the state-of-the-art technology for alluvial filtration for Plasmid-DNA clarification. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX® depth filters are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m2 filter area can be drastically increased.
Save one process step The main advantage of alluvial filtration for the clarification step of Plasmid-DNA is the elimination of the two-step approach. Due to the increased filtration capacity the traditional approaches such as centrifugation followed by depth filtration or a two-step depth filtration are not necessary anymore. The simultaneous reduction of impurities e.g. HCP is another advantage.
Find out more on our PURADISC® BIO SD webpage or contact our filtration experts:
FILTROX has developed Carbon Pads and Carbon Envelopes with, and for foodservice operators, specifically for the filtration and treatment of frying oil.
No need for „polishing“ as the oil only needs one pass through the filter. The frying oil is cleaner after filtration and therefore lasts longer. You use less oil, offer consistent food quality, save labor costs and have an easier and safer operation.
Available in a variety of sizes and types: Carbon Pad, Pleated Carbon Pad, Carbon Envelope.
Find out more on our webpage or contact our filtration experts:
In the age of dry hopping, brewers are searching for more efficient ways to clarify their beer. One of the major challenges is high particulate loads or shorter storage times. This will eventually lead to early filter blockages, shorter filtration cycles and subsequently downtime.
In order to increase capacity and filter life, we have developed a new FIBRAFIX® filter sheet. The new FIBRAFIX® AF 11H filter sheet with unique partial perforation technology combines all advantages brewers are looking for when pre-filtering or polishing their hazy beers.
The ideal sheet for pre-filtration when hopping or for polishing naturally cloudy beers!
20% more surface compared to regular filter sheets.
15% more capacity than regular filter sheets.
DE free filter material.
Lowest driploss results in an economic filtration.
Find out more on our webpage or contact our filtration experts:
Single-use and traditional approach of clarification
The ongoing optimization of mammalian cell lines and fermentation processes leads to higher cell densities/titers and higher monoclonal antibody (mAb) yields. Due to this optimization also the biomass increases, including cell debris and other impurities, which challenges the clarification/harvest step.
The typical clarification process for mammalian cells and mAb involves a primary and a secondary clarification step. Due to potentially high shear forces and the necessity of this step to remove submicron particles, depth filtration is a mandatory step before transferring the liquid into the downstream.
The process combines low running costs with operating robustness.
Find out more on our webpage or contact our filtration experts:
Most countries in which we are active have started to ease their lock-down rules and our business is classified as an essential activity. We have enough stock of necessary raw materials and components and have not experienced any major disruptions in our supply chain. Therefore, we currently do not see any impending risks to our operational stability.
A Clear Solution – FILTROX Hard Seltzer Filtration
Hard Seltzer. Since the demand for low calorie drinks is growing, hard seltzer products have been successfully implemented by many beverage producers. Are you looking for hard seltzer filtration solutions? Due to the different raw materials and challenging fermentation conditions, achieving the highest quality in the final seltzer product can be quite the challenge. Usually after fermentation, the beverage is visually hazy with a slight color.
Get the product ready for flavor addition without too much time and effort with FILTROX depth filtration solutions!
Highest product quality
Quickest set-up time and lowest product losses
Simple and safe manual handling
Sustainable filtration solution
Best aroma & taste preservation
Find out more on our webpage or contact our filtration experts:
Clarification for vaccines – the economic and efficient removal of cell debris and negatively charged molecules with FILTRODISC™ BIO SD and FILTRODISC™ R2U depth filter modules.
The purification of vaccines is a critical step during their complex production process. Cells and cell debris, as well as unwanted contaminants such as host cell proteins (HCPs) and nucleic acids need to be removed, while ensuring an optimal product yield. FILTROX offers a variety of filtration solutions to meet the specific needs for vaccine clarification.
A well-established and efficient technology is alluvial (or body feed) filtration with filter aids such as diatomaceous earth. Lenticular filter modules (FILTRODISC™) can be easily applied to combine the exceptional filtration capacity of filter aids with the advantages of using an enclosed filter housing (DISCSTAR™).
To further optimize pharmaceutical processes, the single use filter modules FILTRODISC™ BIO SD for alluvial filtration and FILTRODISC™ R2U (Ready2Use) for standard depth filtration of less turbid fluids are the best solution for eliminating cross-contamination risks and reducing cleaning validation efforts. This technology is easy to implement and linear scalable from lab to production.
Linear scaleup from lab to production.
Reductionof costs and productionsteps by saving the centrifuge step.
Single-use solution eliminates cross-contamination risks and reduces cleaning validation efforts.
SPECIFIC IMPURITIES TO REMOVE?
To address the removal of specific impurities, filter sheets containing adsorbants with functional properties such as cationic resins (PURAFIX® CH ZP) and activated carbon (CARBOFIL™) are used.
Find out more on our webpage or contact our filtration experts:
Thankfully, FILTROX always has been and still is 100% operational. All our manufacturing sites are running on a normal schedule and our regional distribution centers and sales offices around the world remain open. We have enough stock of necessary raw materials and components and have not experienced any major disruptions in our supply chain. Therefore, we currently do not see any impending risks to our operational stability.
From laboratory to production scale. How to find the optimal solution for your filtration process. From laboratory trials to estimate the perfect filter sheet to calculation for your individual production scale. Read the application note: https://bit.ly/2XS4leh
The new FIBRAFIX® AF 11H filter sheet with unique partial perforation technology combines all advantages brewers are looking for when pre-filtering or polishing their hazy beers.
20 % more surface compared to regular filter sheets.
15 % more capacity than regular filter sheets.
DE free filter material.
Lowest driploss results in a economic filtration.
The unique partial perforation technology for a special surface gives perfect filtration performance where liquids with a heavy load of particulates have to be filtered.
DUROFIL® is our new support sheet, specifically designed for the challenges of pre-coat filtration in the food and beverage industry. Thanks to its unique strength the sheet withstand even highest forces. The filter cake can be removed easily. Find out more about the support sheet.
Currently, we are still 100% operational. All our manufacturing sites are running. Therefore, we can currently ship all purchase orders within normal lead times.
However, we are experiencing some problems with outgoing freight such as limited container availability, reduced airfreight capacity and more time-consuming border-crossing procedures. We are also aware that the situation could change quickly due to higher levels of infections and/or more severe restrictions on the free movement of people and goods.
We are monitoring the situation continuously and will advise immediately of any changes. If you have any questions or concerns, please do not hesitate to contact us.
First of we hope that you, your families and your businesses have not been affected too much by the Corona-Crisis.
Thankfully, FILTROX is still 100% operational. All our manufacturing sites are running on a normal schedule and our regional distribution centers and sales offices around the world are open. As at most companies, our staffing levels are reduced due to safety and quarantine measures. However, this has not affected our operational stability due to flexible work schedules and home-office solutions. We have enough stock of necessary raw materials and components and have not experienced any major disruptions in our supply chain.
An Economical Solution for Midstream Clarification
Introduction Continuous process optimization is a key factor in the biotech industry. With higher particle loads (>108 cells/ml), standard technologies for cell removal (midstream processing) – e.g. centrifugation, separation, membrane- and depth filtration – find their limits.
To increase efficiency and making the midstream process more economical alluvial filtration is the state-of-the-art solution. Alluvial filtration is a type of depth filtration and a well-established, econo-mical method in pharmaceutical industries (e.g. plasma fractionation). Instead of using an immobilized depth filter medium, filter aid (e.g. diatomaceous earth, perlite) is used to constantly build a filter cake during filtration. The filter cake with its resistance acts then as the actual filter medium. Alluvial filtration, therefore, leads to a higher filter capacity – especially with compressible particles, e.g. microbial or mammalian cells. This technology leads to a maximum product yield and highest economic efficiency and is linear scalable from lab to production scale.
Producing pure and safe CBD products is the goal of every quality-conscious manufacturer of cannabis products. Raw hemp extracts contain high concentrations of cannabinoids, but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Why certain contaminants should be removed:
Chlorophyll: • bitter taste and highly unstable • will cause degradation of cannabinoids
Waxes: • very sticky components • removal leads to smoother texture and consistency
Filtration and purification steps of CBD products and oils
In order to ensure product quality and safety, filtration is essential. To remove the waxes, fats and oil from the winterization a multi-step filtration is recommended. Depending on the batch size different approaches are possible. Find out more about the filtration steps. more…
Would you like to get to know us personally and find out more about our depth filtration solutions? Visit us at MJBizCon in Las Vegas, Dec 11-13, 2019 / Stand C9238. MJBizCon, is the largest gathering of cannabis business professionals in the world. With 35,000 attendees and programming to benefit every sector, there is no place like it to equip your business for growth. We look forward to meeting you there. more about MJBizCon
Depth filter modules for high temperature applications and/or demands on chemical resistance in food & beverage, chemical and pharmaceutical industries.
There are several ways to extract the CBD rich oil for therapeutic use from the dried and heated buds. The most common extraction methods are ethanol and CO2 extraction. To find out more about the cannabis oil filtration possibilities.
